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IL2 inducible T-cell kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Itk (2) Btk (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1)

3

Inhibitors & Agonists

3

Recombinant Proteins

1

Antibodies

Targets Recommended: Itk Salt-inducible Kinase (SIK) TOPK NAMPT ALCAM/CD166 GDNF Receptor HIF/HIF Prolyl-Hydroxylase AIM2 BCL6 Tim3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ITK degrader 1	Itk	Cancer
ITK degrader 1 is a highly selective degrader of **interleukin-2-inducible T-cell kinase (ITK; DC₅₀*=3.6 nM in vivo* in mice). ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC₅₀=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo. ITK degrader 1 also shows good plasma exposure levels .

CTA056	Btk	Cancer
CTA056 is an ITK (IL-2-inducible T-cell kinase) inhibitor with an IC₅₀ of 0.1 μM. CTA056 selectively targets malignant T cells and modulates oncomirs. CTA056 induces apoptosis and is a potential therapeutic agent for the research of T-cell leukemia and lymphoma .

ITK/TRKA-IN-1	Itk	Inflammation/Immunology
ITK/TRKA-IN-1 is a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and *tropomyosin receptor kinase* A (TRKA) with an IC₅₀** value of 1.0 nM and 96 % inhibition, respectively.

Recombinant Proteins Recommended:

IL-2 Inducible T-Cell Kinase (ITK/TSK)

Species:	Human (2) Mouse (1)
Tag:	His (1) GST (3)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

	ITK Protein, Mouse (sf9, His-GST) Tyrosine-protein kinase ITK/TSK; IL-2-inducible T-cell kinase; ITK; EMT; LYK	Mouse	Sf9 insect cells
	ITK protein is a tyrosine kinase that plays a crucial role in directing adaptive immune responses by controlling the development, function, and differentiation of conventional T cells and unconventional NKT cells. After T cell receptor (TCR) activation by antigen-presenting cells (APC), ITK is recruited to the cell membrane and phosphorylated by LCK, thereby making it fully activated. ITK Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived ITK protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of ITK Protein, Mouse (sf9, His-GST) is 269 a.a., with molecular weight of ~58 kDa.

	ITK Protein, Human (sf9, GST) Tyrosine-protein kinase ITK/TSK; IL-2-inducible T-cell kinase; ITK; EMT; LYK	Human	Sf9 insect cells
	ITK protein is an important tyrosine kinase that regulates adaptive immune responses by affecting the development and function of T cells and NKT cells. Upon T cell receptor (TCR) activation, ITK undergoes LCK-mediated phosphorylation, leading to its activation. ITK Protein, Human (sf9, GST) is the recombinant human-derived ITK protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of ITK Protein, Human (sf9, GST) is 269 a.a., with molecular weight of ~57.7 kDa.

	ITK Protein, Human (620a.a, sf9, GST) ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell itk/tsk; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; MGC126257; MGC126258	Human	Sf9 insect cells

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